Details:
- Location: Nottingham Nottinghamshire
- Date: 2 months ago
Description:
Ophthalmology Bioassay Senior Scientist
Nottingham | On-site
We are seeking an Ophthalmology Bioassay Senior Scientist to join a growing, innovative CRO environment focused on developing next-generation human-relevant disease models.
This role sits at the forefront of moving drug discovery away from traditional animal models, with a strong emphasis on advanced in vitro systems, including iPSC-derived models and 3D organoids for ocular diseases.
You will play a key role in building and developing capability in ophthalmology, contributing to both project delivery and the longer-term growth of this area of the business. This is an excellent opportunity for someone who enjoys combining hands-on lab work, scientific innovation, and commercial impact.
Responsibilities:
Ocular Model Development
Develop and optimise human-relevant ocular disease models
Design and implement iPSC-derived systems, including retinal and epithelial models
Contribute to the development of complex 3D organoid and co-culture systemsAssay Development & Delivery
Design and execute bioassays relevant to ocular disease, including:
Imaging and fluorescence-based assays
Immunoassays
Functional and translational assays
Analyse and interpret experimental data and present findings clearly to stakeholdersMolecular & Cell Biology
Apply molecular biology techniques including:
Gene knockdown approaches (e.g. siRNA, shRNA)
Work with primary cells, cell lines, and stem-cell derived models
Support development of increasingly complex and physiologically relevant systemsProject Delivery & Growth
Support delivery of CRO projects across drug discovery programmes
Troubleshoot experimental challenges and drive continuous improvement
Contribute to building and scaling ophthalmology capability, including future team growth
Engage with clients and support scientific discussions where required
About You
You are a scientist with strong hands-on experience in advanced cellular models, particularly within ophthalmology or closely related disease areas.
You'll bring:
Experience working with iPSC-derived systems and/or 3D organoid models (critical)
Strong laboratory experience across bioassays, imaging, and molecular biology techniques
Experience working with ocular models or strong transferable cell biology experience
A proactive, problem-solving mindset with the ability to work independentlyDesirable (but not essential):
PhD in Ophthalmology, Cell Biology, Stem Cell Biology, or a related discipline
Experience in a CRO or fast-paced applied research environment
Exposure to replacing or reducing animal models with human-relevant systems
Interest in helping build or grow a new scientific capability or team
If you're excited by organoids, stem cell models, and reducing reliance on animal testing, this role will give you the platform to make a real impact.
Apply now by attaching your CV in Word, or contact Paige Keenan for further information about this new role:
Guidant, Carbon60, Lorien & SRG - The Impellam Group Portfolio are acting as an Employment Business in relation to this vacancy